Search results for " dorsal geniculate neurons"

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mGluR control of interneuron output regulates feedforward tonic GABAA inhibition in the visual thalamus

2011

Metabotropic glutamate receptors (mGluRs) play a crucial role in regulation of phasic inhibition within the visual thalamus. Here we demonstrate that mGluR-dependent modulation of interneuron GABA release results in dynamic changes in extrasynaptic GABAA receptor (eGABAAR)-dependent tonic inhibition in thalamocortical (TC) neurons of the rat dorsal lateral geniculate nucleus (dLGN). Application of the group I selective mGluR agonist dihydroxyphenylglycine produces a concentration-dependent enhancement of both IPSC frequency and tonic GABAA current (IGABAtonic) that is due to activation of both mGluR1a and mGluR5 subtypes. In contrast, group II/III mGluR activation decreases both IPSC freque…

InterneuronReceptors metabotropic glutamateAction PotentialsMetabotropic glutamate receptors GABA dorsal geniculate neurons ratNeurotransmissionReceptors Metabotropic GlutamateQ1DihydroxyphenylglycineSynaptic TransmissionSettore BIO/09 - Fisiologiagamma-Aminobutyric acidArticlechemistry.chemical_compoundThalamusKidney glomerulusInterneuronsmedicineAnimalsVisual Pathwaysgamma-Aminobutyric AcidChemistryGABAA receptorGeneral Neurosciencemusculoskeletal neural and ocular physiologyNeural InhibitionReceptors GABA-ARatsElectrophysiologymedicine.anatomical_structureInhibitory Postsynaptic Potentialsnervous systemMetabotropic glutamate receptorRC0321GABAergicNeuronNeurosciencemedicine.drug
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